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Science 30 April 1976:
Vol. 192. no. 4238, pp. 471 - 473
DOI: 10.1126/science.176728
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Articles

Science, Vol 192, Issue 4238, 471-473
Copyright © 1976 by American Association for the Advancement of Science

articles

Neurotransmitter regulation of adenosine 3',5'-monophosphate in clonal nerve, glia, and muscle cell lines

D Schubert, H Tarikas, and M LaCorbiere

Norepinephrine increases the intracellular level of adenosine 3',5'-monophosphate (cyclic AMP) in clonal cell lines of nerve, glia, smooth muscel, and skeletal muscle. The largest response is in skeletal muscle, where the cyclic nucleotide concentration is elevated more than 500-fold. Glia and muscle cells, but not nerve cells, respond to dopamine with increased cyclic AMP accumulation. This response appears to be mediated through a beta-adrenoreceptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Possibility of Autocrine {beta}-Adrenergic Signaling in C2C12 Myotubes.
J. L. Smith, P. B. Patil, S. D. Minteer, J. R. Lipsitz, and J. S. Fisher (2005)
Experimental Biology and Medicine 230, 845-852
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