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Science 23 April 1976:
Vol. 192. no. 4237, pp. 372 - 374
DOI: 10.1126/science.1257770
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Articles

Science, Vol 192, Issue 4237, 372-374
Copyright © 1976 by American Association for the Advancement of Science

articles

Growth promotion by homocysteic acid

P Clopath, VC Smith, and KS McCully

Homocysteic acid, H03SCH2CH2CHNH2CO2H, promotes growth of hypophysectomized rats, assayed by observation of increased thickness of epiphyseal cartilage of the tibia and by observation of tail growth. Doses of homocysteic acid as low as 1 microgram per day for 4 days in the tibia assay and 2.5 milligrams per kilogram per day for 5 weeks in the tail assay were effective in promoting growth. Serum somatomedin activity, determined by the porcine cartilage disk assay, was also increased by homocysteic acid. These findings relate an area of sulfur amino acid metabolism to the physiological action of growth hormone, accelerated growth in homocystinuria, initiation of arteriosclerosis, and control of cellular growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Homocysteine, Folate, Vitamin B6, and Cardiovascular Disease.
K. S. McCully (1998)
JAMA 279, 392-393
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