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Science 2 April 1976:
Vol. 192. no. 4234, pp. 64 - 66
DOI: 10.1126/science.769160
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Articles

Science, Vol 192, Issue 4234, 64-66
Copyright © 1976 by American Association for the Advancement of Science

articles

Insulin-dependent diabetes: a disease of autoaggression

SW Huang and NK Maclaren

Lymphocytes from patients with insulin-dependent diabetes demonstrated significant cytoadherence and cytotoxicity against human insulinoma cells in vitro as compared to lymphocytes from normals. Complement was not involved in insulinoma cell destruction. The findings suggest that insulin-dependent diabetes may be a disease of autoaggression.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diabetes Mellitus, Islet-Cell Antibodies, and HLA-B8 in a Patient With Systemic Lupus Erythematosus.
L. S. Fruman (1977)
Arch Pediatr Adolesc Med 131, 1252-1254
   Abstract »    PDF »
Viral and Immunological Bases of Beta Cell Failure in Insulin-Dependent Diabetes.
N. K. Maclaren (1977)
Arch Pediatr Adolesc Med 131, 1149-1154
   Abstract »    PDF »
Genetic, Acquired, and Related Factors in the Etiology of Diabetes Mellitus.
O. P. Ganda and S. S. Soeldner (1977)
Arch Intern Med 137, 461-469
   Abstract »    PDF »


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