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Science 2 April 1976:
Vol. 192. no. 4234, pp. 60 - 62
DOI: 10.1126/science.1257757
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Articles

Science, Vol 192, Issue 4234, 60-62
Copyright © 1976 by American Association for the Advancement of Science

articles

Tin: a potent inducer of heme oxygenase in kidney

A Kappas and MD Maines

Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.


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