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Science 26 March 1976:
Vol. 191. no. 4233, pp. 1273 - 1275
DOI: 10.1126/science.1257748
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Articles

Science, Vol 191, Issue 4233, 1273-1275
Copyright © 1976 by American Association for the Advancement of Science

articles

Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats

RA Wise, RA Yokel, and H DeWit

Rats learned to press a lever for intravenous injections of amphetamine or apomorphine. They also learned to avoid the taste of saccharin which was associated with experimenter-administered amphetamine or with self-administered apomorphine. Thus these, and presumably other, self-administered drugs serve as compound pharmacological stimuli, having both positively reinforcing and aversive properties.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amphetamine-Induced Place Preference and Conditioned Motor Sensitization Requires Activation of Tyrosine Kinase Receptors in the Hippocampus.
F. Shen, G. E. Meredith, and T. C. Napier (2006)
J. Neurosci. 26, 11041-11051
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Behavior maintained by termination of a schedule of self-administered cocaine.
R. Spealman (1979)
Science 204, 1231-1233
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