Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 March 1976:
Vol. 191. no. 4231, pp. 1050 - 1051
DOI: 10.1126/science.175444
Prev | Table of Contents | Next

Articles

Science, Vol 191, Issue 4231, 1050-1051
Copyright © 1976 by American Association for the Advancement of Science

articles

Angiotensin-converting enzyme: vascular endothelial localization

PR Caldwell, BC Seegal, KC Hsu, M Das, and RL Soffer

Fluorescein-labeled antibody to rabbit pulmonary angiotensin-converting enzyme localized in the vascular endothelium of rabbit lung, liver, adrenal cortex, pancreas, kidney, and spleen. Epithelial cells of the renal proximal tubules were the only parenchymal cells among the organs studied that demonstrated immunoreactivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Propofol Attenuates Endotoxin-Induced Endothelial Cell Injury, Angiotensin-Converting Enzyme Shedding, and Lung Edema.
E. G. Votta-Velis, R. D. Minshall, D. J. Visintine, M. Castellon, and I. V. Balyasnikova (2007)
Anesth. Analg. 105, 1363-1370
   Abstract »    Full Text »    PDF »
Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice.
S. P. Kessler, P. deS. Senanayake, C. Gaughan, and G. C. Sen (2007)
FASEB J 21, 156-166
   Abstract »    Full Text »    PDF »
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
   Abstract »    Full Text »    PDF »
AT1 Receptor Blockade Regulates the Local Angiotensin II System in Cerebral Microvessels From Spontaneously Hypertensive Rats.
J. Zhou, J. Pavel, M. Macova, Z.-X. Yu, H. Imboden, L. Ge, T. Nishioku, J. Dou, E. Delgiacco, and J. M. Saavedra (2006)
Stroke 37, 1271-1276
   Abstract »    Full Text »    PDF »
Arterial Hemodynamics in Patients After Kawasaki Disease.
H. Senzaki, C.-H. Chen, H. Ishido, S. Masutani, T. Matsunaga, M. Taketazu, T. Kobayashi, N. Sasaki, S. Kyo, and Y. Yokote (2005)
Circulation 111, 2119-2125
   Abstract »    Full Text »    PDF »
Hepatocyte Growth Factor Regulates Angiotensin Converting Enzyme Expression.
R. M. Day, G. Thiel, J. Lum, R. D. Chevere, Y. Yang, J. Stevens, L. Sibert, and B. L. Fanburg (2004)
J. Biol. Chem. 279, 8792-8801
   Abstract »    Full Text »    PDF »
Alzheimer disease risk and genetic variation in ACE: A meta-analysis.
J. S. Elkins, V. C. Douglas, and S. C. Johnston (2004)
Neurology 62, 363-368
   Abstract »    Full Text »    PDF »
Modern Aspects of Cutaneous Neurogenic Inflammation.
M. Steinhoff, S. Stander, S. Seeliger, J. C. Ansel, M. Schmelz, and T. Luger (2003)
Arch Dermatol 139, 1479-1488
   Abstract »    Full Text »    PDF »
Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme.
C. F. Santos, M. A. V. Caprio, E. B. Oliveira, M. C. O. Salgado, D. N. Schippers, D. H. Munzenmaier, and A. S. Greene (2003)
Am J Physiol Heart Circ Physiol 285, H775-H783
   Abstract »    Full Text »    PDF »
Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: ACE and non-ACE mediated effect of angiotensin I on intracellular calcium mobilization in rat glomerular arterioles.
J. Marchetti, C. M. B. Helou, C. Chollet, R. Rajerison, and F. Alhenc-Gelas (2003)
Am J Physiol Heart Circ Physiol 284, H1933-H1941
   Abstract »    Full Text »    PDF »
In vivo measurement of coronary circulation angiotensin-converting enzyme activity in humans.
C. Staniloae, A. J. Schwab, A. Simard, R. Gallo, I. Dyrda, G. Gosselin, J. Lesperance, J. W. Ryan, and J. Dupuis (2003)
Am J Physiol Heart Circ Physiol 284, H17-H22
   Abstract »    Full Text »    PDF »
Possible Activation of the Renin-Angiotensin System in the Feto-Placental Unit in Preeclampsia.
M. Ito, A. Itakura, Y. Ohno, M. Nomura, T. Senga, T. Nagasaka, and S. Mizutani (2002)
J. Clin. Endocrinol. Metab. 87, 1871-1878
   Abstract »    Full Text »    PDF »
Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting.
S. M. Danilov, V. D. Gavrilyuk, F. E. Franke, K. Pauls, D. W. Harshaw, T. D. McDonald, D. J. Miletich, and V. R. Muzykantov (2001)
Am J Physiol Lung Cell Mol Physiol 280, L1335-L1347
   Abstract »    Full Text »    PDF »
Effect of Enalapril on Exhaled Nitric Oxide in Normotensive and Hypertensive Subjects.
H. Sumino, T. Nakamura, T. Kanda, K. Sato, T. Sakamaki, T. Takahashi, Y. Saito, J. Hoshino, T. Kurashina, and R. Nagai (2000)
Hypertension 36, 934-940
   Abstract »    Full Text »    PDF »
Vascular Endothelial Growth Factor Induces Nephrogenesis and Vasculogenesis.
A. TUFRO, V. F. NORWOOD, R. M. CAREY, and R. A. GOMEZ (1999)
J. Am. Soc. Nephrol. 10, 2125-2134
   Abstract »    Full Text »
Tissue Inhibition of Angiotensin-Converting Enzyme Activity Stimulates Angiogenesis In Vivo.
J.-E. Fabre, A. Rivard, M. Magner, M. Silver, and J. M. Isner (1999)
Circulation 99, 3043-3049
   Abstract »    Full Text »    PDF »
Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant eNOS gene.
M. Tsutsui, H. Onoue, Y. Iida, L. Smith, T. O'Brien, and Z. S. Katusic (1999)
Am J Physiol Heart Circ Physiol 276, H1846-H1852
   Abstract »    Full Text »    PDF »
Increased Chymase-Dependent Angiotensin II Formation in Human Atherosclerotic Aorta.
M. Ihara, H. Urata, A. Kinoshita, J. Suzumiya, M. Sasaguri, M. Kikuchi, M. Ideishi, and K. Arakawa (1999)
Hypertension 33, 1399-1405
   Abstract »    Full Text »    PDF »
Human Spiral Artery Renin-Angiotensin System.
T. Morgan, C. Craven, and K. Ward (1998)
Hypertension 32, 683-687
   Abstract »    Full Text »    PDF »
A Cyclic AMP Response Element in the Angiotensin-converting Enzyme Gene and the Transcription Factor CREM Are Required for Transcription of the mRNA for the Testicular Isozyme.
S. P. Kessler, T. M. Rowe, J. A. Blendy, R. P. Erickson, and G. C. Sen (1998)
J. Biol. Chem. 273, 9971-9975
   Abstract »    Full Text »    PDF »
Endothelial regrowth after arterial injury: from vascular repair to therapeutics.
E. Van Belle, C. Bauters, T. Asahara, and J. M. Isner (1998)
Cardiovasc Res 38, 54-68
   Full Text »    PDF »
Angiotensin II Generation at the Cell Surface of Activated Neutrophils: Novel Cathepsin G-Mediated Catalytic Activity That Is Resistant to Inhibition.
C. A. Owen and E. J. Campbell (1998)
J. Immunol. 160, 1436-1443
   Abstract »    Full Text »    PDF »
Endothelin-Converting Enzyme: Ultrastructural Localization and Its Recycling From the Cell Surface.
K. Barnes, C. Brown, and A. J. Turner (1998)
Hypertension 31, 3-9
   Abstract »    Full Text »    PDF »
Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II.
D. N. Muller, J. Bohlender, K. F. Hilgers, D. Dragun, O. Costerousse, J. Menard, and F. C. Luft (1997)
Hypertension 29, 98-104
   Abstract »    Full Text »
Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease.
F. Diet, R. E. Pratt, G. J. Berry, N. Momose, G. H. Gibbons, and V. J. Dzau (1996)
Circulation 94, 2756-2767
   Abstract »    Full Text »
Thrombomodulin and Angiotensin-Converting Enzyme Activity During Pediatric Open Heart Operations.
H. Komai and S. G. Haworth (1996)
Ann. Thorac. Surg. 62, 553-558
   Abstract »    Full Text »
Cigarette smoking and cardiovascular disease.
J.Y. Jeremy, D.P. Mikhailidis, and R.M. Pittilo (1995)
Perspectives in Public Health 115, 289-295
Angiotensin II Contributes to Cerebral Vasodilatation During Hypoxia in the Rabbit.
M. A. Maktabi, M. M. Todd, and G. Stachovic (1995)
Stroke 26, 1871-1876
   Abstract »    Full Text »
The Cyclic AMP Response Elements of the Genes for Angiotensin-converting Enzyme and Phosphoenolpyruvate Carboxykinase (GTP) Can Mediate Transcriptional Activation by CREM[IMAGE] and CREMalpha.
T. Y. Goraya, S. P. Kessler, P. Stanton, R. W. Hanson, and G. C. Sen (1995)
J. Biol. Chem. 270, 19078-19085
   Abstract »    Full Text »    PDF »
Age and Hypertension Differently Affect Coronary Contractions to Endothelin-1, Serotonin, and Angiotensins.
M.R. Tschudi and T.F. Luscher (1995)
Circulation 91, 2415-2422
   Abstract »    Full Text »
A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study.
R. K. Mattu, E. W. A. Needham, D. J. Galton, E. Frangos, A. J. L. Clark, and M. Caulfield (1995)
Circulation 91, 270-274
   Abstract »    Full Text »
Serum Angiotensin-Converting Enzyme Level Is Elevated in Patients With Human Immunodeficiency Virus Infection.
D. R. Ouellette, J. W. Kelly, and G. T. Anders (1992)
Arch Intern Med 152, 321-324
   Abstract »    PDF »
Angiotensin-Converting Enzyme Activity: A Potential Marker of Tissue Hypothyroidism in Critical Illness.
R. C. Smallridge, B. Chernow, R. Snyder, G. P. Zaloga, and K. D. Burman (1985)
Arch Intern Med 145, 1829-1832
   Abstract »    PDF »
Serum Angiotensin-Converting Enzyme in Severe Nonthyroidal Illnesses Associated with Low Serum Thyroxine Concentration.
G. A. BRENT, J. M. HERSHMAN, A. W. REED, A. SASTRE, and J. LIEBERMAN (1984)
Ann Intern Med 100, 680-683
   Abstract »    PDF »
Serum Angiotensin-Converting Enzyme: Alterations in Hyperthyroidism, Hypothyroidism, and Subacute Thyroiditis.
R. C. Smallridge, J. Rogers, and P. S. Verma (1983)
JAMA 250, 2489-2493
   Abstract »    PDF »
Elevation of Serum Angiotensin-Converting Enzyme Level: Occurrence in Alcoholic Liver Disease.
S. A. Borowsky, J. Lieberman, S. Strome, and A. Sastre (1982)
Arch Intern Med 142, 893-895
   Abstract »    PDF »
Increased Levels of Serum Angiotensin-Converting Enzyme Activity in Hyperthyroidism.
H. YOTSUMOTO, Y. IMAI, N. KUZUYA, H. UCHIMURA, and F. MATSUZAKI (1982)
Ann Intern Med 96, 326-328
   Abstract »    PDF »
Serum Angiotensin-Converting Enzyme in Leprosy and Coccidioidomycosis.
J. LIEBERMAN and T. H. REA (1977)
Ann Intern Med 87, 422-425
   Abstract »    PDF »
Angiotensin converting enzyme: induction by steroids in rabbit alveolar macrophages in culture.
J Friedland, C Setton, and E Silverstein (1977)
Science 197, 64-65
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)