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Science 6 February 1976:
Vol. 191. no. 4226, pp. 478 - 480
DOI: 10.1126/science.1246632
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Articles

Science, Vol 191, Issue 4226, 478-480
Copyright © 1976 by American Association for the Advancement of Science

articles

"Serotonin depression"--a biochemical subgroup within the affective disorders?

M Asberg, P Thoren, L Traskman, L Bertilsson, and V Ringberger

The distribution of 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the cerebrospinal fluid of 68 depressed patients was bimodal. Twenty-nine percent of the patients were in the lower mode, with a concentration of 5-HIAA below 15 nanograms per milliliter. Although there were no differences in overall severity of depression between the two modes, there was a significant correlation between the concnetration of 5-HIAA and severity of depression in the lower, but not in the upper, mode. The finding suggests the existence of a biochemical subgroup of depressive disorder, characterized by a disturbance of serotonin turnover.


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Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: I. Enhanced Response in Depression and Mania.
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Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: II. Relation to Suicide, Psychosis, and Depressive Symptoms.
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CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania: A Controlled, Univariate Analysis.
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Monoamine Metabolites in CSF and Suicidal Behavior.
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Plasma Tryptophan and Five Other Amino Acids in Depressed and Normal Subjects.
M. K. DeMyer, P. A. Shea, H. C. Hendrie, and N. N. Yoshimura (1981)
Arch Gen Psychiatry 38, 642-646
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Clomipramine Treatment of Obsessive-Compulsive Disorder: II. Biochemical Aspects.
P. Thoran, M. Asberg, L. Bertilsson, B. Mellstrum, F. Sjuqvist, and L. Traskman (1980)
Arch Gen Psychiatry 37, 1289-1294
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Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients.
G. C. Sedvall and B. Wode-Helgodt (1980)
Arch Gen Psychiatry 37, 1113-1116
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Cortisol in the CSF of Depressed and Suicidal Patients.
L. Traskman, G. Tybring, M. Asberg, L. Bertilsson, O. Lantto, and D. Schalling (1980)
Arch Gen Psychiatry 37, 761-767
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A. J. Mandell and S. Knapp (1979)
Arch Gen Psychiatry 36, 909-916
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Clomipramine-Induced Mania in Unipolar Depression.
J. D. van Scheyen and D. P. van Kammen (1979)
Arch Gen Psychiatry 36, 560-565
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Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response.
R. M. Post, R. H. Gerner, J. S. Carman, J. C. Gillin, D. C. Jimerson, F. K. Goodwin, and W. E. Bunney Jr (1978)
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Psychiatry.
D. X. Freedman (1978)
JAMA 239, 510-512
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Chronic, Multiple Tics of Gilles de la Tourette's Disease: CSF Acid Monoamine Metabolites After Probenecid Administration.
D. J. Cohen, B. A. Shaywitz, B. Caparulo, J. G. Young, and M. B. Bowers Jr (1978)
Arch Gen Psychiatry 35, 245-250
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The Switch Process in Manic-Depressive Psychosis.
W. E. BUNNEY Jr., T. R. WEHR, J. C. GILLIN, R. M. POST, F. K. GOODWIN, and D. P. van KAMMEN (1977)
Ann Intern Med 87, 319-335
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The Human Platelet: A Diagnostic and Research Tool for the Study of Biogenic Amines in Psychiatric and Neurologic Disorders.
S. M. Stahl (1977)
Arch Gen Psychiatry 34, 509-516
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5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?.
M. Asberg, L. Traskman, and P. Thoren (1976)
Arch Gen Psychiatry 33, 1193-1197
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