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Science 30 January 1976:
Vol. 191. no. 4225, pp. 392 - 394
DOI: 10.1126/science.1246620
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Articles

Science, Vol 191, Issue 4225, 392-394
Copyright © 1976 by American Association for the Advancement of Science

articles

Genetic characteristics of the HeLa cell

SH Hsu, BZ Schacter, NL Delaney, TB Miller, VA McKusick, RH Kennett, JG Bodmer, D Young, and WF Bodmer

The genotype of the patient Henrietta Lacks from whose cervical carcinoma the HeLa cell was derived was deduced from the phenotypes of her husband and children, and from studies of the HeLa cell. Hemizygous expression of glucose-6-phosphate dehydrogenase in HeLa, together with the deduced heterozygosity of Mrs. Lacks, is consistent with clonal origin of her neoplasm.


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Identification of distal regulatory regions in the human alpha IIb gene locus necessary for consistent, high-level megakaryocyte expression.
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Cross-contamination of cells in culture.
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Inter- and intraspecies contamination of human breast tumor cell lines HBC and BrCa5 and other cell cultures.
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Enzyme polymorphisms as genetic signatures in human cell cultures.
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Genetics and Serology of HL-A-linked Human Ia Antigens.
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