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Science 23 January 1976:
Vol. 191. no. 4224, pp. 297 - 299
DOI: 10.1126/science.1246615
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Articles

Science, Vol 191, Issue 4224, 297-299
Copyright © 1976 by American Association for the Advancement of Science

articles

Messenger RNA induction of fast sodium ion channels in cultured cardiac myoblasts

MJ McLean, J Renaud, N Sperelakis, and MC Niu

Incubation with adult heart messenger RNA caused the appearance of fast sodium ion channels in young myocardial cells whose development has been arrested in vitro. The induction was blocked by cycloheximide, indicating dependence on protein synthesis. Thus, cardiac myoblasts can be made to differentiate in vitro, and membrane properties can be altered by exogenous RNA.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)