Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 January 1976:
Vol. 191. no. 4224, pp. 295 - 297
DOI: 10.1126/science.1246614
Prev | Table of Contents | Next

Articles

Science, Vol 191, Issue 4224, 295-297
Copyright © 1976 by American Association for the Advancement of Science

articles

Preneoplastic lesions in the human breast

HM Jensen, Rice JR, and Wellings SR

A subgross sampling technique with histological confirmation was used to study the pathology of 119 whole human breasts, either cancer-associated (that is, containing cancer or contralateral to a cancer) or taken from random routine autopsies. Atypical lobules were observed much more frequently in the cancer-associated group than in the group of routine autopsy breasts. Atypical lobules showed varying degrees of anaplasia that formed a continuum between normal epithelium and carcinoma in situ, usually of the common ductal type. As apprarent markers for increased cancer risk, atypical lobules in the human breast may be homologous to hyperplastic alveolar nodules that are abundant in high mammary cancer strains of mice. This indirect evidence supports the hypothesis that atypical lesions are common preneoplastic lesions in the human mammary gland.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ductal Carcinoma In Situ, Complexities and Challenges.
G. D. Leonard and S. M. Swain (2004)
J Natl Cancer Inst 96, 906-920
   Abstract »    Full Text »    PDF »
Morphologic Features and Incidence of Spontaneous Hyperplastic and Neoplastic Mammary Gland Lesions in Wistar Rats.
N. J. Barsoum, A. W. Gough, J. M. Sturgess, and F. A. de la Iglesia (1984)
Toxicol Pathol 12, 26-38
   Abstract »    PDF »
Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer.
H. Jensen, I Chen, M. DeVault, and A. Lewis (1982)
Science 218, 293-295
   Abstract »    PDF »
Neuroleptic-induced Prolactin Level Elevation and Breast Cancer: An Emerging Clinical Issue.
P. M. Schyve, F. Smithline, and H. Y. Meltzer (1978)
Arch Gen Psychiatry 35, 1291-1301
   Abstract »    PDF »
Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.
S. Brem, P. Gullino, and D Medina (1977)
Science 195, 880-882
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)