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Science 16 January 1976:
Vol. 191. no. 4223, pp. 197 - 199
DOI: 10.1126/science.942799
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Articles

Science, Vol 191, Issue 4223, 197-199
Copyright © 1976 by American Association for the Advancement of Science

articles

Nucleus suprachiasmaticus: the biological clock in the hamster?

MH Stetson and M Watson-Whitmyre

Destruction of the suprachiasmatic nuclei in the golden hamster by bilateral radiofrequency lesions abolishes three well-documented circadian rhythms--locomotor activity, estrous cyclicity, and photoperiodic photosensitivity. Entrainment of these rhythms by light cycles fails in lesioned hamsters; females become persistently estrous; in both sexes locomotor activity becomes sporadic, confined primarily to the light instead of darkness, and is totally arrhythmic when lesioned animals are exposed to continuous darkness; the photoperiodic gonadal response (gonadal regression induced by short day lengths) is abolished; lesioned animals remain reproductively mature irrespective of photoperiodic treatment.


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Regulation of circadian rhythmicity.
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Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker.
W. Schwartz and H Gainer (1977)
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Suprachiasmatic nuclear lesions do not abolish food-shifted circadian adrenal and temperature rhythmicity.
D. Krieger, H Hauser, and L. Krey (1977)
Science 197, 398-399
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Estradiol shortens the period of hamster circadian rhythms.
L. Morin, K. Fitzgerald, and I Zucker (1977)
Science 196, 305-307
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Circadian organization in lizards: the role of the pineal organ.
H Underwood (1977)
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