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Science 16 January 1976:
Vol. 191. no. 4223, pp. 191 - 192
DOI: 10.1126/science.1108195
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Articles

Science, Vol 191, Issue 4223, 191-192
Copyright © 1976 by American Association for the Advancement of Science

articles

The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells

RL Pictet, LB Rall, P Phelps, and WJ Rutter

It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eiliminated.


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