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Science 9 January 1976:
Vol. 191. no. 4222, pp. 90 - 92
DOI: 10.1126/science.1246599
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Articles

Science, Vol 191, Issue 4222, 90-92
Copyright © 1976 by American Association for the Advancement of Science

articles

Extracellular potassium accumulation and inward-going potassium rectification in voltage clamped ventricular muscle

L Cleemann and M Morad

Measurements of afterpotential, action potential duration, and output of a potassium-sensitive microelectrode indicate that the application of long clamp pulses (1 to 8 seconds) to frog ventricular muscle is accompanied by a change in the extracellular potassium concentration. The plot of the magnitude of the potassium accumulation against the clamped membrane potential yields an N-shaped relation similar to the "steady state" current-voltage relation. The accumulation studies confirm a strong inward-going (anomalous) potassium rectification.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)