Science, Vol 190, Issue 4221, 1302-1304
Copyright © 1975 by American Association for the Advancement of Science
Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury
SM Sabesin,
LB Kuiken,
and
JB Ragland
Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.
