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Science 12 December 1975:
Vol. 190. no. 4219, pp. 1112 - 1114
DOI: 10.1126/science.1188390
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Articles

Science, Vol 190, Issue 4219, 1112-1114
Copyright © 1975 by American Association for the Advancement of Science

articles

Axonal projections of medial preoptic and anterior hypothalamic neurons

LC Conrad and DW Pfaff

Projections from medial preoptic area (mPOA) and medial anterior hypothalamic area (mAHA) neurons were investigated in albino rats with the use of tritiated amino acid autoradiography. Both the mPOA and the mAHA gave long-axon projections to structures in limbic forebrain and midbrain as well as short-axon projections to other hypothalamic regions. Differences between mPOA and mAHA neurons were observed in projections to the mid-septal region, ventromedial hypothalamus, premammillary region, and central gray. Further, while axons from the mPOA traveled within the medial forebrain bundle, those from the mAHA remained in a band ventromedial to the fornix. These anatomical differences may underlie functional differences between the mPOA and mAHA which have been demonstrated with other experimental techniques.


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