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Science 12 December 1975:
Vol. 190. no. 4219, pp. 1096 - 1097
DOI: 10.1126/science.1188387
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Articles

Science, Vol 190, Issue 4219, 1096-1097
Copyright © 1975 by American Association for the Advancement of Science

articles

Deoxycorticosterone-adenine interactions in a crystalline complex

CM Weeks, DC Rohrer, and WL Duax

Deoxycorticosterone-adenine monohydrate is the first complex involving a steroid and a component of DNA to be successfully crystallized and studied by single crystal x-ray analysis. Hydrogen bonds between O(20) and N(6) as well as O(21) and N(1) connect the corticoid side chain to an adenine molecule. The molecules are also packed such that a second adenine moiety is situated over the delta4-3-one region of the steroid. These observations of the solid state suggest ways in which steroids and nucleic acids may interact in vivo.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)