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Science 28 November 1975:
Vol. 190. no. 4217, pp. 893 - 894
DOI: 10.1126/science.1059262
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Articles

Science, Vol 190, Issue 4217, 893-894
Copyright © 1975 by American Association for the Advancement of Science

articles

Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis

A Leder, S Orkin, and P Leder

Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both).


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