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Science 21 November 1975:
Vol. 190. no. 4216, pp. 787 - 789
DOI: 10.1126/science.1198095
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Articles

Science, Vol 190, Issue 4216, 787-789
Copyright © 1975 by American Association for the Advancement of Science

articles

Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate

JK Reddy and TP Krishnakantha

Two hypolipidemic compounds [ 4-chloro-6(2,3-xylidino)-2-pyrimidinyl-thio] acetic acid, and 2-chloro-5(3,5-dimethylpiperidinosufony)benzoic acid (tibric acid) greatly increased the number of peroxisomes (microbodies) in liver cells of rats and mice. This augmented peroxisome population was accompanied by significant elevation of liver catalase activity. These two hypolipidemic peroxisome proliferators are structurally different from ethyl a-p-chlorophenozyisobutyrate (clofibrate) and other hypolipidemic, arylocyisobutyrate derivatives which cause hepatic peroxisome proliferation. Induction of peroxisome proliferation by these structurally unrelated hypolipidemic compounds suggests a possible relation between hepatic peroxisome proliferation and hypolipidemia.


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