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Science 21 November 1975:
Vol. 190. no. 4216, pp. 784 - 785
DOI: 10.1126/science.1105786
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Articles

Science, Vol 190, Issue 4216, 784-785
Copyright © 1975 by American Association for the Advancement of Science

articles

Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells

DG Walker

Capacity to resorb bone and calcified cartilage was restored permanently in mice with inherited osteopetrosis by the intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates. Beginning near active growth plates as early as 2 weeks after transplantation, replacement of the abnormal spongiosa continued until medullary cavitites were fully expanded.


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