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Science 31 October 1975:
Vol. 190. no. 4213, pp. 473 - 475
DOI: 10.1126/science.1166316
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Articles

Science, Vol 190, Issue 4213, 473-475
Copyright © 1975 by American Association for the Advancement of Science

articles

Parathyroid hormone and 25-hydroxy vitamin D3: synergistic and antagonistic effects on renal phosphate transport

JB Puschett and WS Beck Jr

The effect on phosphate excretion of graded doses of parathyroid hormone (PTH) and the biologically active vitamin D3 metabolite, 25-hydroxycholecalciferol (25-HCC), administered singly and in combination, were studied in the nonexpanded, vitamin D-depleted thyroparathyroidectomized rat. Infusion of 1 unit of 25-HCC per hour for 6 hours induced an antiphosphaturia only when administered with 0.2 units of PTH per hour, while neither agent alone changed phosphate excretion. A dose of 2.0 units of PTH per hour did not cause phosphaturia unless given with 1 unit of 25-HCC per hour. In pharmacologic dosage (5 units per hour), PTH produced phosphaturia in the absence of the metabolite.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vitamin D Endocrinology.
H. F. DeLUCA (1976)
Ann Intern Med 85, 367-377
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