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Science 31 October 1975:
Vol. 190. no. 4213, pp. 465 - 467
DOI: 10.1126/science.170682
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Articles

Science, Vol 190, Issue 4213, 465-467
Copyright © 1975 by American Association for the Advancement of Science

articles

Electron microscopy of albumin synthesis

C Lin and J Chang

Albumin molecules appeared to be synthesized in the light hepatocytes of rats by bound polysomers on rough and endoplasmic reticulum and the nuclear envelope. The molecules were discharged directly into the cytosol, then to the external cellular spaces. This conclusion failed to support the current theory from biochemical studies that albumin is synthesized by bound ribosomes, discharged into the cisternae of rough endoplasmic reticulum, and transported to the smooth endoplasmic reticulum and then to the Golgi apparatus. In addition to the liver, positive syntheic activities were observed in the aorta, kidney, and hepatoma cells of rat. Earlier investigators have reported that only liver cells can synthesize albumin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)