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Science 17 October 1975:
Vol. 190. no. 4211, pp. 289 - 290
DOI: 10.1126/science.1179211
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Articles

Science, Vol 190, Issue 4211, 289-290
Copyright © 1975 by American Association for the Advancement of Science

articles

Antibody formation in first and second generation offspring of nutritionally deprived rats

RK Chandra

Prolonged partial restriction of calorie intake in young rats results in reduced growth, involution of lymphoid organs, and lymphopenia. After immunization with sheep red blood cells, the number of antibody-forming cells in the spleen and serum hemolysin titers are markedly reduced. The effect is more pronounced on the primary response and on immunoglobulin G antibody-forming cells. Significant impairment of antibody formation is detectable in the first (F1) and second (F2) generation offspring of starved Fo mothers.


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