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Science 17 October 1975:
Vol. 190. no. 4211, pp. 278 - 280
DOI: 10.1126/science.1101380
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Articles

Science, Vol 190, Issue 4211, 278-280
Copyright © 1975 by American Association for the Advancement of Science

articles

Complement-mediated bactericidal system: evidence for a new pathway of complement action

SC Moreau and RC Skarnes

The early components of human complement (C1, C4, and C2) plus certain serum euglobulins will kill pathogenic strains of Shigella sonnei. Serum from patients with hereditary C3 deficiencies and specific antiserums to C3, C5, and C6 were utilized to demonstrate the absence of requirements for late-acting complement components in this unusual bactericidal system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)