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Science 10 October 1975:
Vol. 190. no. 4210, pp. 161 - 163
DOI: 10.1126/science.1166307
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Articles

Science, Vol 190, Issue 4210, 161-163
Copyright © 1975 by American Association for the Advancement of Science

articles

Monthly gonadotropin cycles in premenarcheal girls

JW Hansen, HJ Hoffman, and GT Ross

Patterns of nocturnal excretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were investigated in 11 girls. Autoregressive digital filtering of low- and high-frequency variations was used to make patterns more apparent. Coincident FSH and LH surges, separated by an interval of 20 to 40 days, were seen in specimens from three of six postmenarcheal girls and three to five premenarcheal girls. This suggests that cyclic hypothalamic-pituitary-ovarian interactions occur before menarche.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endocrinology in Preadolescents and Adolescents: I. Hormonal Changes During Normal Puberty.
P. C. Sizonenko (1978)
Arch Pediatr Adolesc Med 132, 704-712
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