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Science 3 October 1975:
Vol. 190. no. 4209, pp. 58 - 60
DOI: 10.1126/science.170677
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Articles

Science, Vol 190, Issue 4209, 58-60
Copyright © 1975 by American Association for the Advancement of Science

articles

Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A

F Murad, H Kimura, HA Hopkins, WB Looney, and CJ Kovacs

Urinary excretion of cyclic guanosine monophosphate (GMP) increased in rats bearing Morris hepatoma 3924A, and a correlation coefficient of .842 was observed comparing nucleotide excretion and tumor size. Irradiation of tumor or 5-fluorouracil administration delayed the increases in urinary cyclic GMP and tumor size. Surgical removal of tumors resulted in a rapid decline in cyclic GMP excretion to baseline levels. Cyclic adenosine monophosphate excretion was not altered by implantation, irradiation, or excision of tumor.


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Cigarette smoke activates guanylate cyclase and increases guanosine 3',5'-monophosphate in tissues.
W. Arnold, R Aldred, and F Murad (1977)
Science 198, 934-936
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Guanosine 3'-5'-Monophosphate in the CSF of Neurological Patients.
M. Trabucchi, C. Cerri, P. F. Spano, and K. Kumakura (1977)
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