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Science 29 August 1975:
Vol. 189. no. 4204, pp. 726 - 727
DOI: 10.1126/science.168640
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Articles

Science, Vol 189, Issue 4204, 726-727
Copyright © 1975 by American Association for the Advancement of Science

articles

Predicting response to endocrine therapy in human breast cancer: a hypothesis

KB Horowitz and WL McGuire

We hypothesize that the presence of progesterone receptors in human breast tumors may be a sensitive marker for predicting response to endocrine therapy. Progesterone receptors were found in 56 percent of tumors with estrogen receptors, but were absent in tumors without estrogen receptors. Preliminary clinical correlations show that only those breast tumors with progesterone receptors regressed after endocrine therapy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammary Tumor Phenotypes in Wild-Type Aging Female FVB/N Mice with Pituitary Prolactinomas.
E. Radaelli, A. Arnold, A. Papanikolaou, R. A. Garcia-Fernandez, S. Mattiello, E. Scanziani, and R. D. Cardiff (2009)
Vet. Pathol. 46, 736-745
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Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer.
R. J. BROOM, P. A. TANG, C. SIMMONS, L. BORDELEAU, A. M. MULLIGAN, F. P. O'MALLEY, N. MILLER, I. L. ANDRULIS, D. M. BRENNER, and M. J. CLEMONS (2009)
Anticancer Res 29, 1557-1562
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Commentary: The Year in Basic Science: Update of Estrogen Plus Progestin Therapy for Menopausal Hormone Replacement Implicating Stem Cells in the Increased Breast Cancer Risk.
K. B. Horwitz (2008)
Mol. Endocrinol. 22, 2743-2750
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A Personalized Approach to Cancer Treatment: How Biomarkers Can Help.
M. J. Duffy and J. Crown (2008)
Clin. Chem. 54, 1770-1779
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Pregnancy and the risk of breast cancer.
K. Britt, A. Ashworth, and M. Smalley (2007)
Endocr. Relat. Cancer 14, 907-933
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Problems With the Progesterone Receptor in Practice?.
V. C. Jordan and R. D. Gelber (2007)
J. Clin. Oncol. 25, 1957-1959
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Discussion.
L. Norton (2007)
Clinical Trials 4, 173-175
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TReP-132 Is a Novel Progesterone Receptor Coactivator Required for the Inhibition of Breast Cancer Cell Growth and Enhancement of Differentiation by Progesterone..
F. Gizard, R. Robillard, B. Gross, O. Barbier, F. Revillion, J.-P. Peyrat, G. Torpier, D. W. Hum, and B. Staels (2006)
Mol. Cell. Biol. 26, 7632-7644
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Progesterone Receptor Loss Correlates with Human Epidermal Growth Factor Receptor 2 Overexpression in Estrogen Receptor-Positive Breast Cancer.
H.-J. Kim, X. Cui, S. G. Hilsenbeck, and A. V. Lee (2006)
Clin. Cancer Res. 12, 1013s-1018s
   Abstract »    Full Text »    PDF »
Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy.
X. Cui, R. Schiff, G. Arpino, C. K. Osborne, and A. V. Lee (2005)
J. Clin. Oncol. 23, 7721-7735
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Aromatase Inhibition: Translation into a Successful Therapeutic Approach.
J. Geisler and P. E. Lonning (2005)
Clin. Cancer Res. 11, 2809-2821
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Progesterone-Independent Effects of Human Progesterone Receptors (PRs) in Estrogen Receptor-Positive Breast Cancer: PR Isoform-Specific Gene Regulation and Tumor Biology.
B. M. Jacobsen, S. A. Schittone, J. K. Richer, and K. B. Horwitz (2005)
Mol. Endocrinol. 19, 574-587
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Proliferative activity in postmenopausal endometrium: the lurking potential for giving rise to an endometrial adenocarcinoma.
E Sivridis and A Giatromanolaki (2004)
J. Clin. Pathol. 57, 840-844
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Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases.
V.-J. Bardou, G. Arpino, R. M. Elledge, C. K. Osborne, and G. M. Clark (2003)
J. Clin. Oncol. 21, 1973-1979
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Amplification of erbB2 and erbB2 Expression Are Superior to Estrogen Receptor Status As Risk Factors for Distant Recurrence in pT1N0M0 Breast Cancer: A Nationwide Population-based Study.
H. Joensuu, J. Isola, M. Lundin, T. Salminen, K. Holli, V. Kataja, L. Pylkkanen, T. Turpeenniemi-Hujanen, K. von Smitten, and J. Lundin (2003)
Clin. Cancer Res. 9, 923-930
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Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells.
J. K. Richer, B. M. Jacobsen, N. G. Manning, M. G. Abel, D. M. Wolf, and K. B. Horwitz (2002)
J. Biol. Chem. 277, 5209-5218
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Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer.
J. Geisler, S. Detre, H. Berntsen, L. Ottestad, B. Lindtjørn, M. Dowsett, and P. E. Lønning (2001)
Clin. Cancer Res. 7, 1230-1236
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Cellular and Molecular Pharmacology of Antiestrogen Action and Resistance.
R. Clarke, F. Leonessa, J. N. Welch, and T. C. Skaar (2001)
Pharmacol. Rev. 53, 25-72
   Abstract »    Full Text »    PDF »
Time-Dependent Relevance of Steroid Receptors in Breast Cancer.
D. Coradini, M. G. Daidone, P. Boracchi, E. Biganzoli, S. Oriana, G. Bresciani, C. Pellizzaro, G. Tomasic, G. Di Fronzo, and E. Marubini (2000)
J. Clin. Oncol. 18, 2702-2709
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BCAR1, a Human Homologue of the Adapter Protein p130Cas, and Antiestrogen Resistance in Breast Cancer Cells.
A. Brinkman, S. van der Flier, E. M. Kok, and L. C. J. Dorssers (2000)
J Natl Cancer Inst 92, 112-120
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Bcar1/p130Cas Protein and Primary Breast Cancer: Prognosis and Response to Tamoxifen Treatment.
S. v. d. Flier, A. Brinkman, M. P. Look, E. M. Kok, M. E. Meijer-van Gelder, J. G. M. Klijn, L. C. J. Dorssers, and J. A. Foekens (2000)
J Natl Cancer Inst 92, 120-127
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Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1.
S. D. Groshong, G. I. Owen, B. Grimison, I. E. Schauer, M. C. Todd, T. A. Langan, R. A. Sclafani, C. A. Lange, and K. B. Horwitz (1997)
Mol. Endocrinol. 11, 1593-1607
   Abstract »    Full Text »
Progesterone Regulated Expression of Flavin-Containing Monooxygenase 5 by the B-Isoform of Progesterone Receptors: Implications for Tamoxifen Carcinogenicity.
M. M. Miller, R. A. James, J. K. Richer, D. F. Gordon, W. M. Wood, and K. B. Horwitz (1997)
J. Clin. Endocrinol. Metab. 82, 2956-2961
   Abstract »    Full Text »    PDF »
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
D. Slamon, G. Clark, S. Wong, W. Levin, A Ullrich, and W. McGuire (1987)
Science 235, 177-182
   Abstract »    PDF »
Tamoxifen in Advanced Male Breast Cancer.
J. Aisner, D. D. Ross, and P. H. Wiernik (1979)
Arch Intern Med 139, 480-481
   Abstract »    PDF »
Mammary cancer: selective action of the estrogen receptor complex.
M Ip, R. Milholland, F Rosen, and U Kim (1979)
Science 203, 361-363
   Abstract »    PDF »
Hormonal Therapy of Breast Cancer: New Approaches and Concepts.
S. S. LEGHA, H. L. DAVIS, and F. M. MUGGIA (1978)
Ann Intern Med 88, 69-77
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Steroid Receptors.
J. A. Holt, T. A. Caputo, and K. M. Kelly (1977)
JAMA 238, 2263-2264
   Abstract »    PDF »
Breast Cancer: Physiological Mechanisms of Steroid Hormone Action as a Guide to Therapy.
A. Segaloff (1977)
Arch Intern Med 137, 1603-1604
   Abstract »    PDF »
Progesterone Receptor in Cystosarcoma Phyllodes.
B. R. Rao and J. S. Meyer (1977)
Arch Surg 112, 620-622
   Abstract »    PDF »
Systemic Therapy for Metastatic Breast Cancer.
C. M. HASKELL, F. C. SPARKS, P. R. GRAZE, and S. G. KORENMAN (1977)
Ann Intern Med 86, 68-80
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