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Science 15 August 1975:
Vol. 189. no. 4202, pp. 561 - 563
DOI: 10.1126/science.1145213

Articles

Science, Vol 189, Issue 4202, 561-563
Copyright © 1975 by American Association for the Advancement of Science


articles

Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants

LH Miller, SJ Mason, JA Dvorak, MH McGinniss, and IK Rothman

Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax.


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