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Science 1 August 1975:
Vol. 189. no. 4200, pp. 384 - 386
DOI: 10.1126/science.238285
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Articles

Science, Vol 189, Issue 4200, 384-386
Copyright © 1975 by American Association for the Advancement of Science

articles

Tetrahedral intermediate in a specific alpha-chymotrypsin inhibitor complex detected by laser Raman spectroscopy

GP Hess and D Seybert

Laser Raman spectroscopy indicates that inhibition of alpha-chymotrypsin by 2-phenylethaneboronic acid occurs in two steps: (i) the formation of a loosely bound complex, in which the boron remains in a trigonal configuration; and (ii) reaction of the boron with a functional group in the catalytic site of the enzyme, resulting in a reversible, stable tetrahedral adduct.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)