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Science 4 July 1975:
Vol. 189. no. 4196, pp. 50 - 51
DOI: 10.1126/science.237322
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Articles

Science, Vol 189, Issue 4196, 50-51
Copyright © 1975 by American Association for the Advancement of Science

articles

Amino acid composition of proteins: Selection against the genetic code

TH Jukes, R Holmquist, and H Moise

Distribution of amino acids in 68 representative proteins is compared with their distribution among 61 codons of the genetic code. Average amounts of lysine, aspartic acid, glutamic acid, and alanine are above the levels anticipated from the genetic code, and arginine, serine, leucine, cysteine, proline, and histidine are below such levels. Arginine plus lysine account for 11.0 percent of codons and aspartic acid plus glutamic acid account for 11.3 percent; thus the average charge is roughly neutral.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Toward Understanding the Cationicity of Defensins: ARG AND LYS VERSUS THEIR NONCODED ANALOGS.
G. Zou, E. de Leeuw, C. Li, M. Pazgier, C. Li, P. Zeng, W.-Y. Lu, J. Lubkowski, and W. Lu (2007)
J. Biol. Chem. 282, 19653-19665
   Abstract »    Full Text »    PDF »
Evidence for Autotrophy via the Reverse Tricarboxylic Acid Cycle in the Marine Magnetotactic Coccus Strain MC-1.
T. J. Williams, C. L. Zhang, J. H. Scott, and D. A. Bazylinski (2006)
Appl. Envir. Microbiol. 72, 1322-1329
   Abstract »    Full Text »    PDF »
Role of Directional Mutation Pressure in the Evolution of the Eubacterial Genetic Code.
S. Osawa, T.H. Jukes, A. Muto, F. Yamao, T. Ohama, and Y. Andachi (1987)
Cold Spring Harb Symp Quant Biol 52, 777-789
   Abstract »    PDF »
beta-Galactosidase and selective neutrality.
R Holmquist (1979)
Science 203, 1012-1014
   Abstract »    PDF »
The Packaging Proteins of Core hnRNP Particles and the Maintenance of Proliferative Cell States.
W. M. LeStourgeon, A. L. Beyer, M. E. Christensen, B. W. Walker, S. M. Poupore, and L. P. Daniels (1978)
Cold Spring Harb Symp Quant Biol 42, 885-898
   Abstract »    PDF »


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