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Science 27 June 1975:
Vol. 188. no. 4195, pp. 1317 - 1319
DOI: 10.1126/science.1170638
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Articles

Science, Vol 188, Issue 4195, 1317-1319
Copyright © 1975 by American Association for the Advancement of Science

articles

Insulin-unresponsive tissues respond to superactive insulin-like material

T Oka and YJ Topper

Insulin-like material prepared from insulin-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bl/6J ob/ob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-like material and insulin are equipotent on the corresponding tissues from lean littermates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)