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Science 20 June 1975:
Vol. 188. no. 4194, pp. 1212 - 1215
DOI: 10.1126/science.1145192
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Articles

Science, Vol 188, Issue 4194, 1212-1215
Copyright © 1975 by American Association for the Advancement of Science

articles

Chronotypic action of theophylline and of pentobarbital as circadian zeitgebers in the rat

CF Ehret, VR Potter, and KW Dobra

In the rat the deep body temperature rhythm, monitored by telemetry, can be reset in a predictable direction by a stimulant (theopylline) and by a depressant (pentobarbital). When the drugs are applied immediately before or during the early active phases of the circadian cycle, the rhythm is set back (phase delay). When applied later, past the thermal peak, theophylline, but not pentobarbital, shifts the rhythm ahead (phase advance). Theophylline and pentobarbital in addition to having a number of already established pharmacological properties are now further identified as chronobiotics: they are drugs that may be used to alter the biological time structure by rephasing a circadian rhythm.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distinct Pharmacological Mechanisms Leading to c-fos Gene Expression in the Fetal Suprachiasmatic Nucleus.
L. P. Shearman and D. R. Weaver (2001)
J Biol Rhythms 16, 531-540
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