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Science 6 June 1975:
Vol. 188. no. 4192, pp. 1013 - 1015
DOI: 10.1126/science.1145184
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Articles

Science, Vol 188, Issue 4192, 1013-1015
Copyright © 1975 by American Association for the Advancement of Science

articles

Vitamin D: 3-deoxy-lalpha-hydroxyvitamin D3, biologically active analog of lalpha-dihydroxyvitamin D3

AW Norman, MN Mitra, WH Okamura, and RM Wing

The ability of chemically synthesized 3-deoxy-lalpha-hydroxyvitamin D3, an analog of the biologically active form of vitamin D3, (lalpha,25-dihydroxyvitamin D3), to stimulate intestinal calcium transport was assessed. The 3-deoxy analog acted significantly more rapidly than vitamin D3 and only slightly slower than lalpha,25-dihydroxyvitamin D3. Comparison of the dose-response curves of these three vitamin D derivatives emphasizes the importance of the 3beta-hydroxyl group to biological activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1{alpha},25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses.
A. W. Norman, W. H. Okamura, M. W. Hammond, J. E. Bishop, M. C. Dormanen, R. Bouillon, H. van Baelen, A. L. Ridall, E. Daane, R. Khoury, et al. (1997)
Mol. Endocrinol. 11, 1518-1531
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