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Scarab Genomics

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Science 16 May 1975:
Vol. 188. no. 4189, pp. 740 - 741
DOI: 10.1126/science.1124397
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Articles

Science, Vol 188, Issue 4189, 740-741
Copyright © 1975 by American Association for the Advancement of Science

articles

Mechanism of insulin-induced paralysis of muscles from potassium-depleted rats

I Kao and AM Gordon

Zinc-free insulin elicited a reduction in the potassium conductance of muscle fibers from potassium-depleted muscle, which led to depolarization, blockage of action-poteintial mechanism, and paralysis. These changes are proposed as the mechanism of insulin-induced paralysis in patients with hypokalemic periodic paralysis. A similar effect by concanavalin a suggests that the effect may be mediated through the insulin receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin acts in hypokalemic periodic paralysis by reducing inward rectifier K current.
R. L. Ruff (1999)
Neurology 53, 1556
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Science. ISSN 0036-8075 (print), 1095-9203 (online)