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Science 18 April 1975:
Vol. 188. no. 4185, pp. 273 - 275
DOI: 10.1126/science.47182
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Articles

Science, Vol 188, Issue 4185, 273-275
Copyright © 1975 by American Association for the Advancement of Science

articles

Mechanism of axonal transport: a proposed role for calcium ions

R Hammerschlag, AR Dravid, and AY Chiu

In vitro axonal transport of tritiated protein decreased 40 to 60 percent when neuronal cell bodies were incubated in calcium-free medium, but was not affected when only nerve trunks were exposed to calcium-free conditions. In addition, calcium-45 was transported along axons at a rate similar to that of rapidly transported tritiated protein. These data are interpreted to suggest that calcium ions are involved in the initiation of axonal transport and in the coupling of transported proteins to the transport system.


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