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Science 11 April 1975:
Vol. 188. no. 4184, pp. 153 - 155
DOI: 10.1126/science.163495
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Articles

Science, Vol 188, Issue 4184, 153-155
Copyright © 1975 by American Association for the Advancement of Science

articles

Electron spin resonance for detecting polyadenylate tracts in RNA's

AM Bobst, TK Sinha, and YE Pan

Electron spin resonance is used to detect RNA's that contain polyadenylate tracts. The method depends on the ability of RNA's that contain polyadenylate sequences to associate with poly(2'-deoxy-2'-fluoro)uridylic acid, which has been spin-labeled with 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidinooxyl. The formation of the hybridization product can be detected by monitoring the decrease in mobility of the spin probe.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)