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Science 4 April 1975:
Vol. 188. no. 4183, pp. 57 - 59
DOI: 10.1126/science.163493
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Articles

Science, Vol 188, Issue 4183, 57-59
Copyright © 1975 by American Association for the Advancement of Science

articles

Prolactin receptors in rat liver: possible induction by prolactin

BI Posner, PA Kelly, and HG Friesen

A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.


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