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Science 28 March 1975:
Vol. 187. no. 4182, pp. 1206 - 1208
DOI: 10.1126/science.163492
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Articles

Science, Vol 187, Issue 4182, 1206-1208
Copyright © 1975 by American Association for the Advancement of Science

articles

Insulin-induced augmentation of lymphocyte-mediated cytotoxicity

TB Strom, RA Bear, and CB Carpenter

Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
2006 Homer W. Smith Lecture: Taming T Cells.
T. B. Strom (2007)
J. Am. Soc. Nephrol. 18, 2824-2832
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Why Control Blood Glucose Levels?.
A. A. Rossini (1976)
Arch Surg 111, 229-233
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