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Science 28 March 1975:
Vol. 187. no. 4182, pp. 1202 - 1203
DOI: 10.1126/science.187.4182.1202
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Articles

Chromatin Structure: Deduced from a Minichromosome

Jack D. Griffith 1

1 Department of Biochemistry, Stacnford University School of Medicine, Stanford, California 94305

Cells lytically infected with simian virus 40 contain viral DNA in the form of very small chromlosomnes (minichromosomes) segmented into 100-A lengths, each segment containing about 200 base pairs of DNA. This form resembles that of eukaryotic chromnosom1es anid is consistent with the model of chromatin structure proposed recently.


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Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle.
M. Penaud-Budloo, C. Le Guiner, A. Nowrouzi, A. Toromanoff, Y. Cherel, P. Chenuaud, M. Schmidt, C. von Kalle, F. Rolling, P. Moullier, et al. (2008)
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Mapping of Abutilon Mosaic Geminivirus Minichromosomes.
M. Pilartz and H. Jeske (2003)
J. Virol. 77, 10808-10818
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Control of Meiotic Recombination and Gene Expression in Yeast by a Simple Repetitive DNA Sequence That Excludes Nucleosomes.
D. T. Kirkpatrick, Y.-H. Wang, M. Dominska, J. D. Griffith, and T. D. Petes (1999)
Mol. Cell. Biol. 19, 7661-7671
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Chromatin Higher Order Structure: Chasing a Mirage?.
K. v. Holde and J. Zlatanova (1995)
J. Biol. Chem. 270, 8373-8376
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In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site..
L Zhang and J D Gralla (1989)
Genes & Dev. 3, 1814-1822
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A nucleoprotein complex mediates the integration of retroviral DNA..
B Bowerman, P O Brown, J M Bishop, and H E Varmus (1989)
Genes & Dev. 3, 469-478
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Intermediates in Homologous Pairing Promoted by RecA Protein and Correlations of Recombination In Vitro and In Vivo.
S.S. Flory, J. Tsang, K. Muniyappa, M. Bianchi, D. Gonda, R. Kahn, E. Azhderian, C. Egner, S. Shaner, and C.M. Radding (1984)
Cold Spring Harb Symp Quant Biol 49, 513-523
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SV40 Morphogenesis.
M. Bina, V. Blasquez, S.-C. Ng, and S. Beecher (1983)
Cold Spring Harb Symp Quant Biol 47, 565-569
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Restriction endonucleases, simian virus 40, and the new genetics.
D Nathans (1979)
Science 206, 903-909
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Polyoma virion and capsid crystal structures.
K. Adolph, D. Caspar, C. Hollingshead, E. Lattman, W. Phillips, and W. Murakami (1979)
Science 203, 1117-1120
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Replication and Structure of Simian Virus 40 Chromosomes.
M. L. DePamphilis, S. Anderson, R. Bar-Shavit, E. Collins, H. Edenberg, T. Herman, B. Karas, G. Kaufmann, H. Krokan, E. Shelton, et al. (1979)
Cold Spring Harb Symp Quant Biol 43, 679-692
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Higher order structure of simian virus 40 chromatin.
U Muller, H Zentgraf, I Eicken, and W Keller (1978)
Science 201, 406-415
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The Structure of Nucleosomes: The Arrangement of Histones in the DNA Grooves and Along the DNA Chain.
A. D. Mirzabekov, V. V. Shick, A. V. Belyavsky, V. L. Karpov, and S. G. Bavykin (1978)
Cold Spring Harb Symp Quant Biol 42, 149-155
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Chromatin Assembly and Transcription in Eggs and Oocytes of Xenopus laevis.
R. A. Laskey, B. M. Honda, A. D. Mills, N. R. Morris, A. H. Wyllie, J. E. Mertz, E. M. De Robertis, and J. B. Gurdon (1978)
Cold Spring Harb Symp Quant Biol 42, 171-178
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The Multifunctional Role of Histone H1, Probed with the SV40 Minichromosome.
J. D. Griffith and G. Christiansen (1978)
Cold Spring Harb Symp Quant Biol 42, 215-226
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Biochemical and Ultrastructural Analysis of SV40 Chromatin.
W. Keller, U. Muller, I. Eicken, I. Wendel, and H. Zentgraf (1978)
Cold Spring Harb Symp Quant Biol 42, 227-244
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Higher-order Structure of Mitotic Chromosomes.
A. Leth Bak and J. Zeuthen (1978)
Cold Spring Harb Symp Quant Biol 42, 367-377
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Assembly of SV40 and Polyoma Minichromosomes during Replication.
C. Cremisi, A. Chestier, and M. Yaniv (1978)
Cold Spring Harb Symp Quant Biol 42, 409-416
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On the Structure of Eukaryotic, Prokaryotic, and Viral Chromatin.
A. J. Varshavsky, V. V. Bakayev, S. A. Nedospasov, and G. P. Georgiev (1978)
Cold Spring Harb Symp Quant Biol 42, 457-473
   Abstract »    PDF »
Electron Microscopic Analysis of Chromosome Metabolism in the Drosophila melanogaster Embryo.
S. L. McKnight, M. Bustin, and O. L. Miller Jr. (1978)
Cold Spring Harb Symp Quant Biol 42, 741-754
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Morphology of Transcriptionally Active Chromatin.
W. W. Franke, U. Scheer, M. Trendelenburg, H. Zentgraf, and H. Spring (1978)
Cold Spring Harb Symp Quant Biol 42, 755-772
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Ribosomal Genes and Their Proteins from Xenopus.
R. H. Reeder, H. L. Wahn, P. Botchan, R. Hipskind, and B. Sollner-Webb (1978)
Cold Spring Harb Symp Quant Biol 42, 1167-1177
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Summary: The Molecular Biology of the Eukaryotic Genome Is Coming of Age.
P. Chambon (1978)
Cold Spring Harb Symp Quant Biol 42, 1209-1234
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Superhelix densities of circular DNA's: a generalized equation for their determination by the bouyant method.
W. Upholt (1977)
Science 195, 891
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Ribosomal genes of Xenopus laevis: evidence of nucleosomes in transcriptionally active chromatin.
R Reeves (1976)
Science 194, 529-532
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Chromosomal subunits in active genes have an altered conformation.
H Weintraub and M Groudine (1976)
Science 193, 848-856
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Nuclear ghosts: a nonmembranous structural component of mammalian cell nuclei.
J. Keller and D. Riley (1976)
Science 193, 399-401
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Cross-linking of DNA in situ as a probe for chromatin structure.
C. Hanson, C. Shen, and J. Hearst (1976)
Science 193, 62-64
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Preparation of Native Chromatin and Damage Caused by Shearing.
M. Noll, J. O. Thomas, and R. D. Kornberg (1975)
Science 187, 1203-1206
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