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Science 14 March 1975:
Vol. 187. no. 4180, pp. 955 - 957
DOI: 10.1126/science.1145181
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Articles

Science, Vol 187, Issue 4180, 955-957
Copyright © 1975 by American Association for the Advancement of Science

articles

Blockade of acetylcholine receptors: a model of myasthenia gravis

S Satyamurti, DB Drachman, and F Slone

In order to block acetylcholine receptors of muscle, the alpha toxin of the Formosan cobra (Naja naja atra) was given intravenously to rats. Electrophysiological and pharmacological changes typical of myasthenia gravis were recorded, including decremental responses to repetitive stimuli, curare sensitivity, neostigmine reversal, and posttetanic phenomena. This model supports the concept that a reduction of available acetylcholine receptors may play an important role in myasthenia gravis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoclonal antibody to acetylcholine receptor: cell line established from thymus of patient with Myasthenia gravis.
I Kamo, S Furukawa, A Tada, Y Mano, Y Iwasaki, T Furuse, N Ito, K Hayashi, and E Satoyoshi (1982)
Science 215, 995-997
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Effect of myasthenic immunoglobulin on acetylcholine receptors of intact mammalian neuromuscular junctions.
E. Stanley and D. Drachman (1978)
Science 200, 1285-1287
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Motor nerve sprouting and acetylcholine receptors.
A Pestronk and D. Drachman (1978)
Science 199, 1223-1225
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Myasthenic immunoglobulin accelerates acetylcholine receptor degradation.
I Kao and D. Drachman (1977)
Science 196, 527-529
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Myasthenia gravis: passive transfer from man to mouse.
K. Toyka, D. Brachman, A Pestronk, and I Kao (1975)
Science 190, 397-399
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