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Science 7 March 1975:
Vol. 187. no. 4179, pp. 850 - 853
DOI: 10.1126/science.1114332
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Articles

Science, Vol 187, Issue 4179, 850-853
Copyright © 1975 by American Association for the Advancement of Science

articles

Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose

C Kennedy, MH Des Rosiers, JW Jehle, M Reivich, F Sharpe, and L Sokoloff

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.


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