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Science 28 February 1975:
Vol. 187. no. 4178, pp. 750 - 752
DOI: 10.1126/science.163487
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Articles

Science, Vol 187, Issue 4178, 750-752
Copyright © 1975 by American Association for the Advancement of Science

articles

Selection of a variant lymphoma cell deficient in adenylate cyclase

HR Bourne, P Coffino, and GM Tomkins

Isoproterenol, a stimulator of adenylate cyclase, was used to select a stable variant clone of mouse lymphosarcoma cells deficient in the enzyme. The inability of four different stimulators to activate cyclic adenosine monophosphate synthesis in the variant, in contrast to its wild-type parent, implies that in normal cells one type of adenylate cyclase molecular can respond to different activators.


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