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Science 28 February 1975:
Vol. 187. no. 4178, pp. 742 - 744
DOI: 10.1126/science.1114319
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Articles

Science, Vol 187, Issue 4178, 742-744
Copyright © 1975 by American Association for the Advancement of Science

articles

Extreme toxicity from combustion products of a fire-retarded polyurethane foam

JH Petajan, KJ Voorhees, SC Packham, RC Baldwin, IN Einhorn, ML Grunnet, BG Dinger, and MM Birky

The products from nonflaming combustion of wood and a trimethylol-propane-based rigid-urethane foam that was not fire-retarded produced elevated carboxyhemoglobin levels but no abnormal neurological effects. However, when this type of foam contained a reactive phosphate fire retardant, the combustion products caused grand mal seizures and death in rats. The toxic combustion product responsible for the seizures has been identified as 4-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2.)octane-1-oxide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats.
J. Rossi III, A. E. Jung, G. D. Ritchie, J. W. Lindsey, and A. F. Nordholm (1998)
Drug Metab. Dispos. 26, 1058-1062
   Abstract »    Full Text »
The Combustion Toxicology of Polyurethane Foams.
G.E. Hartzell (1992)
Journal of Cellular Plastics 28, 330-358
   PDF »
High Temperature Decomposition of Military Specification L-23699 Synthetic Aircraft Lubricants.
J. F. Wyman, M. Porvaznik, P. Serve, D. Hobson, and D. E. Uddin (1987)
Journal of Fire Sciences 5, 162-177
   Abstract »    PDF »
The Combustion Toxicology of Polyvinylchloride Revisited.
J.E. Doe (1987)
Journal of Fire Sciences 5, 228-247
   Abstract »    PDF »
Production of a Bicyclophosphate Neurotoxic Agent During Pyrolysis of Synthetic Lubricant Oil.
D. A. Kalman, K. J. Voorhees, D. Osborne, and I.N. Einhorn (1985)
Journal of Fire Sciences 3, 322-329
   Abstract »    PDF »
Evaluation of Smoke Toxicity Using Concentration-Time Products.
G. V. Alexeeff and S. C. Puckham (1984)
Journal of Fire Sciences 2, 362-379
   Abstract »    PDF »
Biological Studies of Combustion Atmospheres.
D.A. Purser and W.D. Woolley (1983)
Journal of Fire Sciences 1, 118-144
   Abstract »    PDF »
Combustion of Several 2,4,5-Trichlorophenoxy Compounds: Formation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
R. H. STEHL and L. L. LAMPARSKI (1977)
Science 197, 1008-1009
   Abstract »    PDF »


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