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Science 21 February 1975:
Vol. 187. no. 4177, pp. 658 - 660
DOI: 10.1126/science.1114316
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Articles

Science, Vol 187, Issue 4177, 658-660
Copyright © 1975 by American Association for the Advancement of Science

articles

Stroke in rats produced by carotid injection of sodium arachidonate

TW Furlow Jr and NH Bass

Unilateral cerebrovascular occlusion was produced in heparinized rats within 60 seconds after an injection of sodium arachidonate (in doses exceeding 0.45 milligram per kilogram) into the carotid artery. Electroencephalographic activity over the affected cerebral hemisphere was suppressed, and cerebral blood flow decreased by half. Microscopic examination revealed complete obstruction of the hemispheric microcirculation by platelet aggregates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Cerebral Thrombosis With Phenytoin in Rats.
S. Tani, T. Shimizu, H. Kasuya, H. Iwasaki, and K. Takashima (1995)
Stroke 26, 2081-2086
   Abstract »    Full Text »
Constriction and Damage of the Pulmonary Artery by Induced Intravascular Aggregation of Platelets.
T. Motomiya, O. Matsuba, and H. Yamazaki (1979)
Vascular and Endovascular Surgery 13, 303-312
   PDF »


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