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Science 14 February 1975:
Vol. 187. no. 4176, pp. 549 - 551
DOI: 10.1126/science.1114314
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Articles

Science, Vol 187, Issue 4176, 549-551
Copyright © 1975 by American Association for the Advancement of Science

articles

Myogenic defect in acetylcholinesterase regulation in muscular dystrophy of the chicken

TA Linkhart, GW Yee, and BW Wilson

To determine whether inherited muscular dystrophy of the chicken is neurogenic or myogenic in origin, limb buds from homozygous normal and dystrophic chick embryos were exchanged prior to muscle differentiation and innervation. Biceps muscles of hatched chicks, in which muscle of the donor was innervated by nerves of the host, were analyzed for embryonic properties of muscle acetylcholinesterase and for fiber diameter, two distinctive markers for expression of the dystrophic gene. The results indicate that muscular dystrophy of the chicken is caused by an initial biochemical lesion in the limb and its muscle rather than in its innervating nerve.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. Rathbone, P. Stewart, and F Vetrano (1975)
Science 189, 1106-1107
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