Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 February 1975:
Vol. 187. no. 4176, pp. 544 - 547
DOI: 10.1126/science.1089999
Prev | Table of Contents | Next

Articles

Science, Vol 187, Issue 4176, 544-547
Copyright © 1975 by American Association for the Advancement of Science

articles

Glucagon: role in the hyperglycemia of diabetes mellitus

R Dobbs, H Sakurai, H Sasaki, G Faloona, I Valverde, D Baetens, L Orci, and R Unger

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Preserved Inhibitory Potency of GLP-1 on Glucagon Secretion in Type 2 Diabetes Mellitus.
K. J. Hare, F. K. Knop, M. Asmar, S. Madsbad, C. F. Deacon, J. J. Holst, and T. Vilsboll (2009)
J. Clin. Endocrinol. Metab. 94, 4679-4687
   Abstract »    Full Text »    PDF »
Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes.
K. Pechhold, X. Zhu, V. S. Harrison, J. Lee, S. Chakrabarty, K. Koczwara, O. Gavrilova, and D. M. Harlan (2009)
Diabetes 58, 1175-1184
   Abstract »    Full Text »    PDF »
Making insulin-deficient type 1 diabetic rodents thrive without insulin.
X. Yu, B.-H. Park, M.-Y. Wang, Z. V. Wang, and R. H. Unger (2008)
PNAS 105, 14070-14075
   Abstract »    Full Text »    PDF »
The Role of Glucagon in Postprandial Hyperglycemia The Jury's Still Out.
J. Bollyky and C. J. Greenbaum (2007)
J. Clin. Endocrinol. Metab. 92, 2879-2881
   Full Text »    PDF »
Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes.
B. Ahren, M. Landin-Olsson, P.-A. Jansson, M. Svensson, D. Holmes, and A. Schweizer (2004)
J. Clin. Endocrinol. Metab. 89, 2078-2084
   Abstract »    Full Text »    PDF »
Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice.
Y. Liang, M. C. Osborne, B. P. Monia, S. Bhanot, W. A. Gaarde, C. Reed, P. She, T. L. Jetton, and K. T. Demarest (2004)
Diabetes 53, 410-417
   Abstract »    Full Text »
Glucagon and Blood Glucose: Insights from Artificial Pancreas Studies.
P. FELIG and R. S. SHERWIN (1980)
Ann Intern Med 92, 856-857
   Abstract »    PDF »
Diabetic Ketoacidosis: New Concepts and Trends in Pathogenesis and Treatment.
R. A. KREISBERG (1978)
Ann Intern Med 88, 681-695
   Abstract »    PDF »
Role of Glucagon in Diabetes.
R. H. Unger and L. Orci (1977)
Arch Intern Med 137, 482-491
   Abstract »    PDF »
Salivary gland hyperglycemic factor: an extrapancreatic source of glucagon-like material.
A. Lawrence, S Tan, S Hojvat, and L Kirsteins (1977)
Science 195, 70-72
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)