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Science 7 February 1975:
Vol. 187. no. 4175, pp. 450 - 451
DOI: 10.1126/science.1111114
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Articles

Science, Vol 187, Issue 4175, 450-451
Copyright © 1975 by American Association for the Advancement of Science

articles

Measles virus: an unwanted variant causing hydrocephalus

MV Haspel and F Rapp

Mutagenization of measles virus with proflavine produced a temperature-sensitive mutant capable of inducing hydrocephalus following intracranial inoculation of newborn hamsters. Hydrocephalus was not produced by the parental strain or by other measles virus mutants. Thus, mutants can be the causative agents of disease not associated with the parental strain. The results dictate caution in the use and distribution of experimentally induced virus variants.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Major Histocompatibility Complex Haplotype Determines hsp70-Dependent Protection against Measles Virus Neurovirulence.
T. Carsillo, M. Carsillo, Z. Traylor, P. Rajala-Schultz, P. Popovich, S. Niewiesk, and M. Oglesbee (2009)
J. Virol. 83, 5544-5555
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The H Gene of Rodent Brain-Adapted Measles Virus Confers Neurovirulence to the Edmonston Vaccine Strain.
W. P. Duprex, I. Duffy, S. McQuaid, L. Hamill, S. L. Cosby, M. A. Billeter, J. Schneider-Schaulies, V. ter Meulen, and B. K. Rima (1999)
J. Virol. 73, 6916-6922
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Pathogenesis of Reovirus Type 1 Hydrocephalus in Mice: Significance of Aqueductal Changes.
C. Masters, M. Alpers, and B. Kakulas (1977)
Arch Neurol 34, 18-28
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Supraependymal cells of hypothalamic third ventricle: identification as resident phagocytes of the brain.
R Bleier, R Albrecht, and J. Cruce (1975)
Science 189, 299-301
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