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Science 31 January 1975:
Vol. 187. no. 4174, pp. 368 - 370
DOI: 10.1126/science.1111112
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Articles

Science, Vol 187, Issue 4174, 368-370
Copyright © 1975 by American Association for the Advancement of Science

articles

Dopamine beta-hydroxylase activity in brains of chronic schizophrenic patients

RJ Wyatt, MA Schwartz, E Erdelyi, and JD Barchas

Postmorten brain specimens from nine chronic schizophrenic patients and nine control were assayed for activity of dopamine beta-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine. Unlike the results of previous reports, there was no statistically significant difference in enzyme activity between the patient and control groups. There were, however, significant negative correlations between dopamin beta-hydroxylase activity and the tim spent in the morgue before autopsy, and between enzyme activity of schizophrenics and dosage of chlorpromazine or its equivalent.


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Behavioral neurochemistry: neuroregulators and behavioral states.
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Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain.
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Dopamine- -Hydroxylase: Basic and Clinical Studies.
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