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Science 24 January 1975:
Vol. 187. no. 4173, pp. 259 - 261
DOI: 10.1126/science.1111100
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Articles

Science, Vol 187, Issue 4173, 259-261
Copyright © 1975 by American Association for the Advancement of Science

articles

2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation

SG Iatridis, PG Iatridis, SG Markidou, and BH Ragatz

2,3-Diphosphoglycerate (2,3-DPG) may inhibit the platelet release reaction and the irreversible aggregation of human blood platelets induced by adenosine diphosphate, epinephrine, or norepinephrine. The effects of 2,3-DPG on platelet aggregation were more pronounced in cases with low hematocrit (less than 30 percent). Dipyridamole and vincaminor potentiated the antiaggregating effect of 2,3-DPG. Erythocytes (10-3 to 10-4 per microliter) exhibited a similar antiaggregating effect, especially when secured from anemic patients.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)