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Science 17 January 1975:
Vol. 187. no. 4172, pp. 177 - 179
DOI: 10.1126/science.1089309
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Articles

Science, Vol 187, Issue 4172, 177-179
Copyright © 1975 by American Association for the Advancement of Science

articles

Vesicular binesis: glucose effect on insulin secretory vesicles

KH Gabbay, J Korff, and EE Schneeberger

Binesis is a process whereby the membrane of the insuline secretory vesicle in the beta cell forms a lingula that indents the vesicular membrane of an adjoining secretory vesicle of the plasma membrane. Vesicular binesis in beta cells increases when islets of Langerhans are incubated at a stimulatory glucose concentration (300 miligrams per 100 milliliters). These vesicular membrane alterations may be the morphological concomitants of activation of the insulin secretory vesicle, and indicate an active role for the vesicle and its membrane in the release mechanism.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)