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Science 17 January 1975:
Vol. 187. no. 4172, pp. 169 - 171
DOI: 10.1126/science.1167425
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Articles

Science, Vol 187, Issue 4172, 169-171
Copyright © 1975 by American Association for the Advancement of Science

articles

Daily rhythm in human urinary melatonin

HJ Lynch, RJ Wurtman, MA Moskowitz, MC Archer, and MH Ho

The melatonin in urine samples from six healthy adult volunteers was concentrated on Amberlite XAD-2 resin, eluted with organic solvents, and quantitated by use of a bioassay technique (the dermal melanaphore response of larval anurans to melatonin in their bathing medium). The melatonin content of samples collected between 11 p.m. and 7 a.m. was, in each case, several times higher than that of samples collected between 7 a.m. and 3 p.m. or between 3 p.m. and 11 p.m.


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